P-Anisidine → HCID 68663378, compound

Participants

Reaction Steps

A solution of methyl 3-fluoro-4-nitrobenzoate (10.0 g, 54.0 mmol) and p-anisidine (13.3 g, 108 mmol) in dimethylsulfoxide (300 mL) was stirred at 70° C. for 3.5 hr. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane/tetrahydrofuran to give the title compound (12.9 g, yield 79%) as red crystals.

Provenance & Evidence