Methyl isothiocyanate → HCID 86640032, compound

HRID 452646Notes

Reaction equation

HRID 452646 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13]3[CH:14]=[C:15]([C:18]([NH:20][NH2:21])=[O:19])[CH:16]=[CH:17][C:12]=3[O:11][CH:10]=2)=[CH:5][CH:4]=1.[CH3:22][N:23]=[C:24]=[S:25]>C(O)C>[CH3:22][NH:23][C:24]([NH:21][NH:20][C:18]([C:15]1[CH:16]=[CH:17][C:12]2[O:11][CH:10]=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([S:2][CH3:1])=[CH:8][CH:7]=3)[C:13]=2[CH:14]=1)=[O:19])=[S:25]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 44480698HCID 44480698, compound

Product 1

HCID 86640032HCID 86640032, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-[4-(methylthio)phenyl]-1-benzofuran-5-carbohydrazide (0.60 g, 2.01 mmol), methyl isothiocyanate (97%, 0.21 g, 2.82 mmol) and ethanol (15 mL) was tightly sealed in a vial, and the microwave was irradiated at 100° C. for 30 min. After cooling, the precipitate was collected by filtration, and washed with ethanol to give the title compound (0.70 g, yield 94%) as colorless crystals.

Workup

  1. customwas tightly sealed in a vial, and the microwave
  2. customwas irradiated at 100° C. for 30 min
  3. temperatureAfter cooling
  4. filtrationthe precipitate was collected by filtration
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-43714ccda99c4bfc92e2d0d9042f8575
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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