(2,5-Difluorophenyl)boronic acid → HCID 68663782, compound

HRID 452651Notes

Reaction equation

HRID 452651 reaction equation
Br[C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1B(O)O>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1

Participants

3

Reactant 2

HCID 2734335(2,5-Difluorophenyl)boronic acidHCID 22481688Methyl 3-bromo-1-benzofuran-5-carboxylate

Product 1

HCID 68663782HCID 68663782, compoundYield 70%

Procedure

In the same manner as in Reference Example 19 and using methyl 3-bromo-1-benzofuran-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and (2,5-difluorophenyl)boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 70%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-28bbbca6ecf348f3a99e74653a06a1bd
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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