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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452653Generated: October 25, 2026

Acetoxyacetyl chloride → 2-Oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetate

https://huagongshe.com/reaction/452653

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetoxyacetyl chlorideHCID 26297—
Reactant3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazideHCID 68664388—
Product2-Oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetateHCID 6866397994%

Reaction Steps

In the same manner as in Reference Example 61 and using 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide instead of ethyl 2-aminoisonicotinate and acetoxyacetyl chloride instead of 3-phenylpropanoyl chloride, the title compound (yield 94%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-b8ee4722838a4af8a11e55105d686a9e
Source noteuspto-grants-2013_07