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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452654Generated: October 25, 2026

2-Acetoxypropionic Acid → 1-Methyl-2-oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetate

https://huagongshe.com/reaction/452654

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Acetoxypropionic AcidHCID 79041—
Reactant3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazideHCID 68664388—
Product1-Methyl-2-oxo-2-[2-[[3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]carbonyl]hydrazino]ethyl acetateHCID 6866412548%

Reaction Steps

In the same manner as in Reference Example 1 and using (±)-2-acetoxypropionic acid instead of benzothiazole-6-carboxylic acid and 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide instead of tert-butyl carbazate, the title compound (yield 48%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-465c29856ff445689dbe99214503ebe4
Source noteuspto-grants-2013_07