Ethyl isothiocyanate → N-ethyl-2-[[1-[4-(methylthio)phenyl]-1H-benzimidazol-6-yl]carbonyl]hydrazinecarbothioamide
Reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]3[CH:14]=[C:15]([C:18]([NH:20][NH2:21])=[O:19])[CH:16]=[CH:17][C:12]=3[N:11]=[CH:10]2)=[CH:5][CH:4]=1.[CH2:22]([N:24]=[C:25]=[S:26])[CH3:23]>>[CH2:22]([NH:24][C:25]([NH:21][NH:20][C:18]([C:15]1[CH:16]=[CH:17][C:12]2[N:11]=[CH:10][N:9]([C:6]3[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[CH:4][CH:5]=3)[C:13]=2[CH:14]=1)=[O:19])=[S:26])[CH3:23]Participants
3
Procedure
In the same manner as in Reference Example 115 and using 1-[4-(methylthio)phenyl]-1H-benzimidazole-6-carbohydrazide instead of 3-[4-(methylthio)phenyl]-1-benzofuran-5-carbohydrazide and ethyl isothiocyanate instead of methyl isothiocyanate, the title compound (yield 90%) was obtained as colorless crystals.
Sources & evidence
- ORD record
- ord-cb3748d98ef14b16b902f8b0cbd0b565
- Source dataset
- uspto-grants-2013_07
- Patent number
- US08492378B2
Reaction notes
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