4-Bromothioanisole → HCID 68663560, compound

HRID 452672Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([S:8][CH3:9])=[CH:4][CH:3]=1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]([O:21][CH3:22])=[O:20])[CH:17]=2)[CH:12]=[CH:11]1>>[CH3:9][S:8][C:5]1[CH:6]=[CH:7][C:2]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([O:21][CH3:22])=[O:20])[CH:17]=3)[CH:12]=[CH:11]2)=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 660374-Bromothioanisole

HCID 639844Methyl indole-6-carboxylate

Product 1

HCID 68663560HCID 68663560, compoundYield 47%

Procedure

In the same manner as in Reference Example 89 and using 1-bromo-4-(methylthio)benzene instead of methyl 2-chloroisonicotinate and methyl 1H-indole-6-carboxylate instead of 2-aminopyridine, the title compound (yield 47%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-2275c84a5e63491ba44f5f9a177e2fc2
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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