2-Chlorophenylboronic acid → HCID 68663314, compound

HRID 452673Notes

Reaction equation

HRID 452673 reaction equation
Br[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=2)[O:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1B(O)O>>[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=2)[O:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 68664009HCID 68664009, compound

Product 1

HCID 68663314HCID 68663314, compoundYield 77%

Procedure

In the same manner as in Reference Example 19 and using methyl 3-bromofuro[2,3-b]pyridine-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and (2-chlorophenyl)boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 77%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-c3bf9560d5324862b926526066afbc21
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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