4-(Methylthio)phenylboronic acid → HCID 44478376, compound

HRID 452674Notes

Reaction equation

HRID 452674 reaction equation
Br[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:9]=2)[O:4][CH:3]=1.[CH3:16][S:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[CH3:16][S:17][C:18]1[CH:23]=[CH:22][C:21]([C:2]2[C:10]3[C:5](=[N:6][CH:7]=[C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:9]=3)[O:4][CH:3]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 68663627HCID 68663627, compound

Product 1

HCID 44478376HCID 44478376, compoundYield 95%

Procedure

In the same manner as in Reference Example 19 and using ethyl 3-bromofuro[2,3-b]pyridine-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and [4-(methylthio)phenyl]boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 95%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-198fa1e4d43748f991c65f6486083fb1
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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