Acetohydrazide → N'-acetyl-3-bromofuro[2,3-c]pyridine-5-carbohydrazide

HRID 452675Notes

Reaction equation

HRID 452675 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][N:7]=[C:8]([C:11]([OH:13])=O)[CH:9]=2)[O:4][CH:3]=1.[C:14]([NH:17][NH2:18])(=[O:16])[CH3:15]>>[C:14]([NH:17][NH:18][C:11]([C:8]1[CH:9]=[C:10]2[C:2]([Br:1])=[CH:3][O:4][C:5]2=[CH:6][N:7]=1)=[O:13])(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 14039AcetohydrazideHCID 220476273-Bromofuro[2,3-c]pyridine-5-carboxylic acid

Product 1

HCID 44478383N'-acetyl-3-bromofuro[2,3-c]pyridine-5-carbohydrazideYield 95%

Procedure

In the same manner as in Reference Example 1 and using 3-bromofuro[2,3-c]pyridine-5-carboxylic acid instead of benzothiazole-6-carboxylic acid and acetohydrazide instead of tert-butyl carbazate, the title compound (yield 95%) was obtained as colorless amorphous.

Sources & evidence

ORD record
ord-e32e8b7814494cb493dc70c0acfdeeea
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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