HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazo(1,2-a)pyridine-6-carboxylic acid, hydrazide → 6-[5-[2-[4-Methoxy-3-(trifluoromethyl)phenyl]ethyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazo(1,2-a)pyridine-6-carboxylic acid, hydrazide | HCID 16413557 | — |
| Reactant | 3-[4-Methoxy-3-(trifluoromethyl)phenyl]propionic acid | HCID 57363570 | — |
| Product | 6-[5-[2-[4-Methoxy-3-(trifluoromethyl)phenyl]ethyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine | HCID 68663168 | 38% |
Reaction Steps
In the same manner as in Example 14 and using imidazo[1,2-a]pyridine-6-carbohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 3-[4-methoxy-3-(trifluoromethyl)phenyl]propionic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 38%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-c389eec4e161464497a6f972da4df1dc |
| Source note | uspto-grants-2013_07 |