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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452687Generated: October 30, 2026

5-(Chloromethyl)-2-methoxybenzonitrile → 2-Methoxy-5-[[[5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile

https://huagongshe.com/reaction/452687

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Chloromethyl)-2-methoxybenzonitrileHCID 22996191—
ReactantHCID 178464120HCID 178464120—
Product2-Methoxy-5-[[[5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrileHCID 6866415356%

Reaction Steps

In the same manner as in Example 1 and using 5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole-2-thiol triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 5-(chloromethyl)-2-methoxybenzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 56%) was obtained as pale-brown crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-f3b9d6aa87c44892893b45104bfb1a95
Source noteuspto-grants-2013_07