HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Chloromethyl)-2-methoxybenzonitrile → 2-Methoxy-5-[[[5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Chloromethyl)-2-methoxybenzonitrile | HCID 22996191 | — |
| Reactant | HCID 178464120 | HCID 178464120 | — |
| Product | 2-Methoxy-5-[[[5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile | HCID 68664153 | 56% |
Reaction Steps
In the same manner as in Example 1 and using 5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole-2-thiol triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 5-(chloromethyl)-2-methoxybenzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 56%) was obtained as pale-brown crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-f3b9d6aa87c44892893b45104bfb1a95 |
| Source note | uspto-grants-2013_07 |