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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452688Generated: October 31, 2026

3-Fluorobenzyl chloride → 7-[5-[(3-Fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl]-1,2,4-triazolo[1,5-a]pyridine

https://huagongshe.com/reaction/452688

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluorobenzyl chlorideHCID 9974—
ReactantHCID 178464120HCID 178464120—
Product7-[5-[(3-Fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl]-1,2,4-triazolo[1,5-a]pyridineHCID 6866329227%

Reaction Steps

In the same manner as in Example 1 and using 5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole-2-thiol triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-fluorobenzyl chloride instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 27%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-85c5b7b91c0248afb31d9c9c91af191c
Source noteuspto-grants-2013_07