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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452689Generated: October 29, 2026

Benzonitrile, 3-(bromomethyl)- → 3-[[[5-(1,2,4-Triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrile

https://huagongshe.com/reaction/452689

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzonitrile, 3-(bromomethyl)-HCID 97249—
ReactantHCID 178464120HCID 178464120—
Product3-[[[5-(1,2,4-Triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzonitrileHCID 6866405720%

Reaction Steps

In the same manner as in Example 1 and using 5-(1,2,4-triazolo[1,5-a]pyridin-7-yl)-1,3,4-oxadiazole-2-thiol triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-(bromomethyl)benzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 20%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-3d4512fc8b4a4f4d8b3bd244c3ed2809
Source noteuspto-grants-2013_07