Ethyl bromoacetate → HCID 86640034, compound

HRID 452692Notes

Reaction equation

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1.Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[CH2:21]([O:20][C:18](=[O:19])[CH2:17][S:15][C:13]1[O:14][C:10]([C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][CH2:3][C:4]=3[CH:9]=2)=[N:11][N:12]=1)[CH3:22]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 178527934HCID 178527934, compound

Product 1

HCID 86640034HCID 86640034, compoundYield 54%

Procedure

In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and ethyl bromoacetate instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 54%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-1971cba2b0e8492b83d6c6ce3c590711
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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