Methyl 4-(bromomethyl)benzoate → HCID 68664256, compound

HRID 452696Notes

Reaction equation

HRID 452696 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1.Br[CH2:17][C:18]1[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:19]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:14][C:13]([S:15][CH2:17][C:18]4[CH:27]=[CH:26][C:21]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:19]=4)=[N:12][N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 178527934HCID 178527934, compound

Product 1

HCID 68664256HCID 68664256, compoundYield 36%

Procedure

In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and methyl 4-(bromomethyl)benzoate instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 36%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-8b93bb6ba0d74ce28a5424cc7c706115
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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