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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452697Generated: October 26, 2026

4-(Chloromethyl)benzoic acid → 4-[[[5-(2,3-Dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acid

https://huagongshe.com/reaction/452697

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)benzoic acidHCID 74234—
ReactantHCID 178527934HCID 178527934—
Product4-[[[5-(2,3-Dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acidHCID 68662883100%

Reaction Steps

In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-(chloromethyl)benzoic acid instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 100%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-2364fe6aefd44f0b99b17e4e36b50ce2
Source noteuspto-grants-2013_07