p-Xylyl bromide → HCID 68663686, compound

HRID 452698Notes

Reaction equation

HRID 452698 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1.[CH3:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21]Br)=[CH:19][CH:18]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[O:14][C:13]([S:15][CH2:16][C:17]4[CH:24]=[CH:23][C:20]([CH3:21])=[CH:19][CH:18]=4)=[N:12][N:11]=3)=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7721p-Xylyl bromideHCID 178527934HCID 178527934, compound

Product 1

HCID 68663686HCID 68663686, compoundYield 75%

Procedure

In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-methylbenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 75%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-e86331740f564af59063852acc491d48
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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