HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)-2-chloro-1-methoxybenzene → 2-[(3-Chloro-4-methoxybenzyl)thio]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)-2-chloro-1-methoxybenzene | HCID 11470370 | — |
| Reactant | HCID 178527934 | HCID 178527934 | — |
| Product | 2-[(3-Chloro-4-methoxybenzyl)thio]-5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole | HCID 44590377 | 87% |
Reaction Steps
In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-chloro-4-methoxybenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 87%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-b8245d12acb34775b344ed46383486bd |
| Source note | uspto-grants-2013_07 |