反应详情

A solution of 2-(2,3-dihydro-1-benzofuran-5-ylcarbonyl)-N-(3-fluorobenzyl)hydrazinecarboxamide (0.50 g, 2.81 mmol), polystyrene resin-immobilized triphenylphosphine (2.15 mmol/g, 0.76 g, 1.64 mmol), triethylamine (0.17 mL, 1.22 mmol) and carbon tetrachloride (0.12 mL, 1.22 mmol) in tetrahydrofuran (5 mL) was stirred at 80° C. for 4 hr. The reaction mixture was filtered, water was added to the filtrate, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane/ethyl acetate to give the title compound (97 mg, yield 51%) as colorless crystals.

1. filtrationThe reaction mixture was filtered
2. additionwater was added to the filtrate
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was recrystallized from hexane/ethyl acetate