HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-1-methoxy-2-(trifluoromethyl)benzene → 2-(1-Benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-1-methoxy-2-(trifluoromethyl)benzene | HCID 53429220 | — |
| Reactant | HCID 178527940 | HCID 178527940 | — |
| Product | 2-(1-Benzofuran-5-yl)-5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazole | HCID 44590416 | 100% |
Reaction Steps
In the same manner as in Example 1 and using 5-(1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-methoxy-3-(trifluoromethyl)benzyl chloride instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 100%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-743fd860427b4af6a62a6e19eb8bbc32 |
| Source note | uspto-grants-2013_07 |