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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452736Generated: October 28, 2026

4-Methoxy-3-(trifluoromethyl)benzyl bromide → 2-[3-(4-Methoxyphenyl)-1-benzofuran-5-yl]-5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazole

https://huagongshe.com/reaction/452736

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxy-3-(trifluoromethyl)benzyl bromideHCID 2775302—
ReactantHCID 178488802HCID 178488802—
Product2-[3-(4-Methoxyphenyl)-1-benzofuran-5-yl]-5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazoleHCID 4459046691%

Reaction Steps

In the same manner as in Example 1 and using 5-[3-(4-methoxyphenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-methoxy-3-(trifluoromethyl)benzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 91%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-3320538b6b024e8d99601e3989b6c0e7
Source noteuspto-grants-2013_07