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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452740Generated: October 25, 2026

3-(Chloromethyl)benzoic acid → 3-[[[5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acid

https://huagongshe.com/reaction/452740

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)benzoic acidHCID 241752—
ReactantHCID 178492021HCID 178492021—
Product3-[[[5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acidHCID 6866395831%

Reaction Steps

In the same manner as in Example 1 and using 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-(chloromethyl)benzoic acid instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 31%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-56b7ed740aea43c38af46bdc134eb460
Source noteuspto-grants-2013_07