3-Fluorobenzyl bromide → HCID 68664207, compound

HRID 452749Notes

Reaction equation

HRID 452749 reaction equation
[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([SH:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[N:12]=[CH:11]2)=[CH:6][CH:5]=1)=[O:3].[F:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29]Br>>[F:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29][S:24][C:22]1[O:23][C:19]([C:16]2[CH:17]=[CH:18][C:13]3[N:12]=[CH:11][N:10]([C:7]4[CH:8]=[CH:9][C:4]([S:2]([CH3:1])=[O:3])=[CH:5][CH:6]=4)[C:14]=3[CH:15]=2)=[N:20][N:21]=1

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 178504605HCID 178504605, compound

Product 1

HCID 68664207HCID 68664207, compoundYield 77%

Procedure

In the same manner as in Example 7 and using 5-[1-[4-(methylsulfinyl)phenyl]-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 3-fluorobenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 77%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-b75854e7605745a8abb2ec1b314b93e5
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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