Benzonitrile, 3-(bromomethyl)- → HCID 68664128, compound

HRID 452750Notes

Reaction equation

[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([SH:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[N:12]=[CH:11]2)=[CH:6][CH:5]=1)=[O:3].Br[CH2:26][C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[C:30]#[N:31]>>[CH3:1][S:2]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([S:24][CH2:26][C:27]5[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=5)[C:30]#[N:31])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[N:12]=[CH:11]2)=[CH:6][CH:5]=1)=[O:3]

Participants

Reactant 2

HCID 97249Benzonitrile, 3-(bromomethyl)-

HCID 178504605HCID 178504605, compound

Product 1

HCID 68664128HCID 68664128, compoundYield 67%

Procedure

In the same manner as in Example 7 and using 5-[1-[4-(methylsulfinyl)phenyl]-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 3-(bromomethyl)benzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 67%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-65dd00895714437d81f4d349c484907a
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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