3-Fluorobenzyl bromide → HCID 86640038, compound

HRID 452755Notes

Reaction equation

HRID 452755 reaction equation
C(N(CC)CC)C.[SH:8][C:9]1[O:13][C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:15]=2)=[N:11][N:10]=1.[F:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=1)[CH2:32]Br>>[C:23]([O:22][C:21](=[O:27])[NH:20][C:16]1[CH:15]=[C:14]([C:12]2[O:13][C:9]([S:8][CH2:32][C:31]3[CH:34]=[CH:35][CH:36]=[C:29]([F:28])[CH:30]=3)=[N:10][N:11]=2)[CH:19]=[CH:18][N:17]=1)([CH3:24])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 178452645HCID 178452645, compound

Product 1

HCID 86640038HCID 86640038, compoundYield 93%

Procedure

In the same manner as in Example 1 and using tert-butyl [4-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-pyridyl]carbamate triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-fluorobenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 93%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-8172818e5cd44a24b6625eed7883fa6e
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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