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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452758Generated: November 2, 2026

4-Methoxy-3-(trifluoromethyl)benzyl bromide → N-[4-[5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazol-2-yl]-2-pyridyl]-3-phenylpropionamide

https://huagongshe.com/reaction/452758

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxy-3-(trifluoromethyl)benzyl bromideHCID 2775302—
ReactantHCID 178520430HCID 178520430—
ProductN-[4-[5-[[4-methoxy-3-(trifluoromethyl)benzyl]thio]-1,3,4-oxadiazol-2-yl]-2-pyridyl]-3-phenylpropionamideHCID 6866369539%

Reaction Steps

In the same manner as in Example 1 and using N-[4-(5-mercapto-1,3,4-oxadiazol-2-yl)-2-pyridyl]-3-phenylpropionamide instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-methoxy-3-(trifluoromethyl)benzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 39%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-5e1755496a0c4b218b62a0434ed18b7c
Source noteuspto-grants-2013_07