3-Fluorobenzyl bromide → HCID 68663669, compound

HRID 452764Notes

Reaction equation

HRID 452764 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][C:9]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)=[C:4]2[CH:3]=[CH:2]1.[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]Br>>[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20][S:15][C:13]1[O:14][C:10]([C:9]2[CH:8]=[CH:7][N:6]=[C:5]3[NH:1][CH:2]=[CH:3][C:4]=23)=[N:11][N:12]=1

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 178527956HCID 178527956, compound

Product 1

HCID 68663669HCID 68663669, compoundYield 64%

Procedure

In the same manner as in Example 1 and using 5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3,4-oxadiazole-2-thiol 5/6 triethylamine salt instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 3-fluorobenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 64%) was obtained as pale-yellow crystals.

Sources & evidence

ORD record
ord-2c8e8790ea3d41c79db109fc88ad21df
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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