HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid → 4-[5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazol-2-yl]-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid | HCID 22477426 | — |
| Reactant | 3-(3-Fluorophenyl)propanohydrazide | HCID 68663733 | — |
| Product | 4-[5-[2-(3-fluorophenyl)ethyl]-1,3,4-oxadiazol-2-yl]-1H-pyrrolo[2,3-b]pyridine | HCID 68663017 | 40% |
Reaction Steps
In the same manner as in Example 14 and using 3-(3-fluorophenyl)propanohydrazide instead of 1H-benzotriazole-5-carbohydrazide and 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid instead of 3-(3-cyanophenyl)propionic acid, the title compound (yield 40%) was obtained as pale-yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-8297be140ed34a47bf3843759385546b |
| Source note | uspto-grants-2013_07 |