HCID 68663654, compound → HCID 68663709, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-phenylethyl)-1H-pyrrolo[2,3-b]pyridine-4-carbohydrazide (104 mg, 0.371 mmol) and ethyl orthoacetate (5 mL) was stirred at 120° C. for 1 hr and at 140° C. for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=4/1-0/1) and basic silica gel column chromatography (hexane/ethyl acetate=4/1-0/1), and recrystallized from hexane/ethyl acetate to give the title compound (85 mg, yield 75%) as pale-yellow crystals.

Provenance & Evidence