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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 452780Generated: October 25, 2026

1-(Bromomethyl)-3-chlorobenzene → 2-[(3-Chlorobenzyl)thio]-5-[3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole

https://huagongshe.com/reaction/452780

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-3-chlorobenzeneHCID 69838—
ReactantHCID 178504596HCID 178504596—
Product2-[(3-Chlorobenzyl)thio]-5-[3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazoleHCID 6866325184%

Reaction Steps

In the same manner as in Example 7 and using 5-[3-[4-(methylsulfinyl)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and 3-chlorobenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 84%) was obtained as colorless crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08492378B2
Source datasetuspto-grants-2013_07
ORD IDord-c6ea24e012ef4a2aae723091fd06977a
Source noteuspto-grants-2013_07