Methylamine tetrahydrofuran → HCID 68663843, compound

HRID 452793Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[C:15]2[CH:16]=[C:17]([C:20]3[O:21][C:22]([CH3:25])=[N:23][N:24]=3)[CH:18]=[CH:19][C:14]=2[O:13][CH:12]=1)[C:5]([OH:7])=O.[CH3:26][NH2:27].O1CCCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[C:15]2[CH:16]=[C:17]([C:20]3[O:21][C:22]([CH3:25])=[N:23][N:24]=3)[CH:18]=[CH:19][C:14]=2[O:13][CH:12]=1)[C:5]([NH:27][CH3:26])=[O:7]

Participants

Reactant 2

HCID 66615946Methylamine tetrahydrofuran

HCID 68663012HCID 68663012, compound

Product 1

HCID 68663843HCID 68663843, compoundYield 21%

Procedure

In the same manner as in Example 117 and using 3-chloro-4-[5-(5-methyl-1,3,4-oxadiazol-2-yl)-1-benzofuran-3-yl]benzoic acid instead of 3-[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]propionic acid and using 2M methylamine-tetrahydrofuran solution instead of N,O-dimethylhydroxyamine hydrochloride, the title compound (yield 21%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-2f1146f725524dc8867b88f860f550e0
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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