Methyl iodide → HCID 68664032, compound

HRID 452802Notes

Reaction equation

HRID 452802 reaction equation
[F:1][C:2]([F:26])([F:25])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]3[CH:15]=[C:16]([C:19]4[O:23][C:22]([SH:24])=[N:21][N:20]=4)[CH:17]=[CH:18][C:13]=3[O:12][CH:11]=2)=[CH:6][CH:5]=1.I[CH3:28]>>[CH3:28][S:24][C:22]1[O:23][C:19]([C:16]2[CH:17]=[CH:18][C:13]3[O:12][CH:11]=[C:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:25])([F:1])[F:26])=[CH:5][CH:6]=4)[C:14]=3[CH:15]=2)=[N:20][N:21]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 178506364HCID 178506364, compound

Product 1

HCID 68664032HCID 68664032, compoundYield 80%

Procedure

In the same manner as in Example 1 and using 5-[3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and using iodomethane instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 80%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-03d40d6b00954776aae0007cddd3500c
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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