HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate | HCID 68664542 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[3-(Trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide | HCID 68664388 | — |
Reaction Steps
A solution of methyl 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate (6.80 g, 20.2 mmol) and hydrazine monohydrate (9.92 mL, 202.2 mmol) in ethanol (70 mL) was heated under reflux overnight. After cooling, the precipitate was collected by filtration to give 3-[3-(trifluoromethoxy)phenyl]-1-benzofuran-5-carbohydrazide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-56e45ac22a3f4ebeb9cfd5ed9852e527 |
| Source note | uspto-grants-2013_07 |