Methyl iodide → HCID 68664326, compound

HRID 452813Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:13]2[CH:14]=[C:15]([C:18]3[O:22][C:21]([SH:23])=[N:20][N:19]=3)[CH:16]=[CH:17][C:12]=2[O:11][CH:10]=1.I[CH3:25]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:13]2[CH:14]=[C:15]([C:18]3[O:22][C:21]([S:23][CH3:25])=[N:20][N:19]=3)[CH:16]=[CH:17][C:12]=2[O:11][CH:10]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 178505805HCID 178505805, compound

Product 1

HCID 68664326HCID 68664326, compoundYield 89%

Procedure

In the same manner as in Example 7 and using 5-[3-(2,5-difluorophenyl)-1-benzofuran-5-yl]-1,3,4-oxadiazole-2-thiol instead of 5-(1H-indazol-5-yl)-1,3,4-oxadiazole-2-thiol and using iodomethane instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 89%) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-9da038dd756b46ad83519365574ea0cc
Source dataset: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08492378B2

Reaction notes

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