4-(Methylthio)phenylboronic acid → HCID 44478650, compound

HRID 452827Notes

Reaction equation

HRID 452827 reaction equation
Br[C:2]1[C:10]2[C:5](=[CH:6][N:7]=[C:8]([C:11]3[O:12][C:13]([CH3:16])=[N:14][N:15]=3)[CH:9]=2)[O:4][CH:3]=1.[CH3:17][S:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[CH3:16][C:13]1[O:12][C:11]([C:8]2[CH:9]=[C:10]3[C:2]([C:22]4[CH:23]=[CH:24][C:19]([S:18][CH3:17])=[CH:20][CH:21]=4)=[CH:3][O:4][C:5]3=[CH:6][N:7]=2)=[N:15][N:14]=1

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 44480950HCID 44480950, compound

Product 1

HCID 44478650HCID 44478650, compoundYield 52%

Procedure

In the same manner as in Example 132 and using 3-bromo-5-(5-methyl-1,3,4-oxadiazol-2-yl)furo[2,3-c]pyridine instead of 2-(3-bromo-1-benzofuran-5-yl)-5-methyl-1,3,4-oxadiazole and using [4-(methylthio)phenyl]boronic acid instead of (4-fluorophenyl)boronic acid, the title compound (yield 52%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-8dfc038c2306444c8e19cf2326776da4
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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