2-Chlorophenylboronic acid → HCID 68663729, compound

HRID 452828Notes

Reaction equation

HRID 452828 reaction equation
Br[C:2]1[C:10]2[C:5](=[CH:6][N:7]=[C:8]([C:11]3[O:12][C:13]([CH3:16])=[N:14][N:15]=3)[CH:9]=2)[O:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1B(O)O>>[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:2]1[C:10]2[C:5](=[CH:6][N:7]=[C:8]([C:11]3[O:12][C:13]([CH3:16])=[N:14][N:15]=3)[CH:9]=2)[O:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 44480950HCID 44480950, compound

Product 1

HCID 68663729HCID 68663729, compoundYield 21%

Procedure

In the same manner as in Example 132 and using 3-bromo-5-(5-methyl-1,3,4-oxadiazol-2-yl)furo[2,3-c]pyridine instead of 2-(3-bromo-1-benzofuran-5-yl)-5-methyl-1,3,4-oxadiazole and using (2-chlorophenyl)boronic acid instead of (4-fluorophenyl)boronic acid, the title compound (yield 21%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-f05bfab976664d0fbe4fc2b63e2193e8
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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