4-(Trifluoromethoxy)phenylboronic acid → HCID 68664026, compound

HRID 452829Notes

Reaction equation

HRID 452829 reaction equation
Br[C:2]1[C:10]2[C:5](=[CH:6][N:7]=[C:8]([C:11]3[O:12][C:13]([CH3:16])=[N:14][N:15]=3)[CH:9]=2)[O:4][CH:3]=1.[F:17][C:18]([F:30])([F:29])[O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:16][C:13]1[O:12][C:11]([C:8]2[CH:9]=[C:10]3[C:2]([C:23]4[CH:22]=[CH:21][C:20]([O:19][C:18]([F:17])([F:29])[F:30])=[CH:25][CH:24]=4)=[CH:3][O:4][C:5]3=[CH:6][N:7]=2)=[N:15][N:14]=1

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 44480950HCID 44480950, compound

Product 1

HCID 68664026HCID 68664026, compoundYield 25%

Procedure

In the same manner as in Example 132 and using 3-bromo-5-(5-methyl-1,3,4-oxadiazol-2-yl)furo[2,3-c]pyridine instead of 2-(3-bromo-1-benzofuran-5-yl)-5-methyl-1,3,4-oxadiazole and using [4-(trifluoromethoxy)phenyl]boronic acid instead of (4-fluorophenyl)boronic acid, the title compound (yield 25%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-75c17cbe34934946b12fd992fb73f526
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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