3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → 5-(5-Methyl-1,3,4-oxadiazol-2-yl)-3-[3-(trifluoromethoxy)phenyl]furo[3,2-b]pyridine

Participants

Reaction Steps

In the same manner as in Example 132 and using 3-bromo-5-(5-methyl-1,3,4-oxadiazol-2-yl)furo[3,2-b]pyridine instead of 2-(3-bromo-1-benzofuran-5-yl)-5-methyl-1,3,4-oxadiazole, using [3-(trifluoromethoxy)phenyl]boronic acid instead of (4-fluorophenyl)boronic acid, and using [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) chloride dichloromethane complex instead of tetrakis(triphenylphosphine)palladium(0), the title compound (yield 57%) was obtained as colorless crystals.

Provenance & Evidence