2-(Bromomethyl)benzonitrile → HCID 68663343, compound

HRID 452838Notes

Reaction equation

HRID 452838 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:16]=[N:17][NH:18][CH:19]=4)[C:11]=3[CH:20]=2)=[N:5][N:6]=1.Br[CH2:22][C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[C:25]#[N:26]>>[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:19]=[N:18][N:17]([CH2:22][C:23]5[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=5[C:25]#[N:26])[CH:16]=4)[C:11]=3[CH:20]=2)=[N:5][N:6]=1

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 68663199HCID 68663199, compound

Product 1

HCID 68663343HCID 68663343, compoundYield 91%

Procedure

In the same manner as in Example 1 and using 2-methyl-5-[3-(1H-pyrazol-4-yl)-1-benzofuran-5-yl]-1,3,4-oxadiazole instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and using 2-(bromomethyl)benzonitrile instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 91%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-6cc09f7b24a34a2c8a50eee8267438a3
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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