1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 68664423, compound

HRID 452839Notes

Reaction equation

HRID 452839 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:16]=[N:17][NH:18][CH:19]=4)[C:11]=3[CH:20]=2)=[N:5][N:6]=1.[F:21][C:22]([F:32])([F:31])[C:23]1[CH:30]=[CH:29][CH:28]=[CH:27][C:24]=1[CH2:25]Br>>[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:19]=[N:18][N:17]([CH2:25][C:24]5[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=5[C:22]([F:21])([F:31])[F:32])[CH:16]=4)[C:11]=3[CH:20]=2)=[N:5][N:6]=1

Participants

3

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 68663199HCID 68663199, compound

Product 1

HCID 68664423HCID 68664423, compoundYield 92%

Procedure

In the same manner as in Example 1 and using 2-methyl-5-[3-(1H-pyrazol-4-yl)-1-benzofuran-5-yl]-1,3,4-oxadiazole instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and using 2-(trifluoromethyl)benzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 92%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-74cc0ef38a774195a5f24f95b779241e
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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