alpha-Bromo-o-fluorotoluene → HCID 68663938, compound

HRID 452840Notes

Reaction equation

HRID 452840 reaction equation
[CH3:1][C:2]1[O:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:14][CH:13]=[C:12]([C:15]4[CH:16]=[N:17][NH:18][CH:19]=4)[C:11]=3[CH:20]=2)=[N:5][N:6]=1.[F:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br>>[F:21][C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][N:18]1[CH:19]=[C:15]([C:12]2[C:11]3[CH:20]=[C:7]([C:4]4[O:3][C:2]([CH3:1])=[N:6][N:5]=4)[CH:8]=[CH:9][C:10]=3[O:14][CH:13]=2)[CH:16]=[N:17]1

Participants

3

Reactant 2

HCID 67968alpha-Bromo-o-fluorotolueneHCID 68663199HCID 68663199, compound

Product 1

HCID 68663938HCID 68663938, compoundYield 88%

Procedure

In the same manner as in Example 1 and using 2-methyl-5-[3-(1H-pyrazol-4-yl)-1-benzofuran-5-yl]-1,3,4-oxadiazole instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and using 2-fluorobenzyl bromide instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 88%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-fa32c4ef97c048d8b33cf1dd387a7f5e
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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