4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic Acid → 1-Cyclobutyl-4-({4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]phenyl}carbonyl) hexahydro-1H-1,4-diazepine hydrochloride

HRID 452879Notes

Reaction equation

HRID 452879 reaction equation
[ClH:1].Cl.[CH:3]1([N:7]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4]1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:22]=[C:23]([C:26]3[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=3)[S:24][CH:25]=2)=[CH:17][CH:16]=1>>[ClH:1].[CH:3]1([N:7]2[CH2:13][CH2:12][CH2:11][N:10]([C:30]([C:29]3[CH:28]=[CH:27][C:26]([C:23]4[S:24][CH:25]=[C:21]([C:18]5[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=5)[N:22]=4)=[CH:34][CH:33]=3)=[O:31])[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 14837074-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic AcidHCID 574239521-Cyclobutyl-1,4-diazepane dihydrochloride

Product 1

HCID 669302661-Cyclobutyl-4-({4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]phenyl}carbonyl) hexahydro-1H-1,4-diazepine hydrochloride

Procedure

The title compound (E8) was prepared from 1-(cyclobutyl)-hexahydro-1H-1,4-diazepine dihydrochloride (D4) and 4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]benzoic acid using the procedure described in Example 7. MS APCI-436 (MH+).

Sources & evidence

ORD record
ord-9848b43308844fd7bf6c173cea178755
Source dataset
uspto-grants-2013_07
Patent number
US08492375B2

Reaction notes

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