Furan, 2-(bromomethyl)tetrahydro- → 5-cyclopropyl-3-(tetrahydrofuran-2-ylmethyl)-1,3,4-thiadiazol-2(3H)-imine

HRID 452940Notes

Reaction equation

HRID 452940 reaction equation
[CH:1]1([C:4]2[S:8][C:7]([NH2:9])=[N:6][N:5]=2)[CH2:3][CH2:2]1.Br[CH2:11][CH:12]1[CH2:16][CH2:15][CH2:14][O:13]1>>[CH:1]1([C:4]2[S:8][C:7](=[NH:9])[N:6]([CH2:11][CH:12]3[CH2:16][CH2:15][CH2:14][O:13]3)[N:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 14501Furan, 2-(bromomethyl)tetrahydro-HCID 7170215-Cyclopropyl-1,3,4-thiadiazol-2-amine

Product 1

HCID 666982515-cyclopropyl-3-(tetrahydrofuran-2-ylmethyl)-1,3,4-thiadiazol-2(3H)-imine

Procedure

5-cyclopropyl-1,3,4-thiadiazol-2-amine (ASD) and 2-(bromomethyl)tetrahydrofuran (Acros) were processed using the method described in Example 1C to afford the title compound.

Sources & evidence

ORD record
ord-2b1e45c5102c4b818e0f3c8a0b8c3287
Source dataset
uspto-grants-2013_07
Patent number
US08492371B2

Reaction notes

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