HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-[1-(Trifluoromethyl)cyclobutyl]-1,3,4-thiadiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Thiosemicarbazide | HCID 2723789 | — |
| Reactant | 1-(Trifluoromethyl)cyclobutanecarboxylic acid | HCID 2782838 | — |
| Product | 5-[1-(Trifluoromethyl)cyclobutyl]-1,3,4-thiadiazol-2-amine | HCID 67545793 | — |
Reaction Steps
Commercially available, 1-(trifluoromethyl)cyclobutanecarboxylic acid (Oakwood), thiosemicarbazide (Aldrich) and phosphorus oxychloride (Aldrich) were processed as described for Example 1A to obtain the title compound. MS (ESI+) m/z 224 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492371B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-7d491b2187d14304abb08b0e2a1e130d |
| Source note | uspto-grants-2013_07 |