HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 5-(2,2,2-Trifluoro-1,1-dimethylethyl)-1,3,4-thiadiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Thiosemicarbazide | HCID 2723789 | — |
| Reactant | 3,3,3-Trifluoro-2,2-dimethylpropanoic acid | HCID 19867367 | — |
| Product | 5-(2,2,2-Trifluoro-1,1-dimethylethyl)-1,3,4-thiadiazol-2-amine | HCID 67545085 | — |
Reaction Steps
Commercially available, 3,3,3-trifluoro-2,2-dimethylpropanoic acid (Matrix), thiosemicarbazide (Aldrich) and phosphorus oxychloride (Aldrich) were processed as described for Example 1A to obtain the title compound. MS (ESI+) m/z 212 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492371B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-3350563dd3b941c8ac09c538dd684e11 |
| Source note | uspto-grants-2013_07 |