反应详情

温度

78 °C

To a solution of 4-benzyloxybenzonitrile (0.61 g, 2.91 mmol) in 15 ml of tert-butanol was added fine powder of KOH (1.22 g, 21.78 mmol) and the resulting reaction mixture was refluxed for 4 h at 78° C. After the completion of the reaction (TLC monitoring), added brine solution and extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum, to get the product (0.67 g) that was used as such for the next step.

1. customthe resulting reaction mixture
2. customAfter the completion of the reaction (TLC monitoring)
3. extractionextracted with ethyl acetate (3×50 ml)
4. dry with materialThe combined organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under vacuum