2-Chloro-5-nitro-3-(trifluoromethyl)pyridine → 5-(Trifluoromethyl)pyridin-3-amine

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Reaction Steps

A mixture of 2-chloro-5-nitro-3-trifluoromethyl-pyridine (30 mg, 0.13 mmol), 10% Pd/C (3 mg, 10% w/w), and MeOH (5 mL) is stirred under 1 atm of hydrogen for 3 h. The mixture is then filtered over Celite® and concentrated in vacuo to give the title compound as an oil. MS (ESI) m/z 162.9 (M+1).

Provenance & Evidence