Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium tert-butoxide → Methyl 1-benzyl-2-methyl-3-oxopiperidine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | Methyl 4-(benzyl(1-ethoxy-1-oxopropan-2-yl)amino)butanoate | HCID 67423852 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 1-benzyl-2-methyl-3-oxopiperidine-4-carboxylate | HCID 67423405 | — |
반응 단계
A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492393B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-4082deae8ee44b37ade099d99f99913f |
| 출처 메모 | uspto-grants-2013_07 |