Trifluoroacetic acid → Ammonium Hydroxide

Participants

Reaction Steps

A solution of 4-[1-(5-tert-butyl-2H-pyrazol-3-ylcarbamoyl)-1H-indol-5-yloxy]-6-methyl-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester (300 mg, 0.55 mmol), DCM (5 mL), and TFA (5 mL) is stirred at rt for 2 h. At that point the solution is concentrated and the residue separated via semi-prep HPLC(C18; 10-100% I/H2O with 0.1% NH4OH) to give the title compound.

Provenance & Evidence